MOTS-C (20mg)

MOTS-c

Supplied as a lyophilized (freeze-dried) white powder in a sealed sterile vial. Requires reconstitution with bacteriostatic water prior to use. Each vial contains 20mg of MOTS-c at ≥99% purity.

MOTS-c is a 16 amino acid mitochondrial-derived peptide (MDP) encoded within the 12S rRNA region of the mitochondrial genome — unusual among mammalian peptides, which are typically nuclear-encoded. First characterised in 2015 by researchers at the University of Southern California, MOTS-c has since become a central focus of metabolic and longevity research. It has been extensively researched for its role in AMPK pathway activation, insulin sensitivity, glucose metabolism, exercise adaptation, and cellular resistance to metabolic stress.

Research Background

Unlike nuclear-encoded peptides, MOTS-c is expressed directly from mitochondrial DNA, positioning it as a key subject in mitochondrial-nuclear communication research. Plasma MOTS-c levels decline with age and correlate with insulin resistance, reduced exercise capacity, and metabolic dysfunction in human observational studies. Mechanistically, MOTS-c translocates from mitochondria to nucleus under metabolic stress and activates AMPK — the master cellular energy regulator also activated by exercise and caloric restriction. In-vitro and preclinical studies have examined its capacity to regulate glucose utilisation via the folate cycle and purine biosynthesis pathways, independent of canonical insulin signalling, and its expression has been observed to increase in skeletal muscle and plasma under physical stress conditions.

Product Specifications

Storage Instructions

Lab Testing & Purity Results

Every batch of MOTS-c is analysed in-house by HPLC and mass spectrometry and ships with a batch-specific Certificate of Analysis; select batches undergo additional independent, third-party purity verification. Our purity results come from real lab tests conducted by our customers and independent researchers, and are published unmodified — only personal details are redacted for privacy.